Duke resView Postearchers have reported that pancreatic alpha cells may be able to produce GLP-1 under certain conditions, suggesting the body has more than one way to influence this hormone pathway
On a 40-pound weight loss, the difference is losing 4-6 pounds of lean mass versus 10-16 pounds
Research Overview Sema is a long-acting GLP-1 receptor agonist that has generated significant scientific interest due to its prolonged receptor activation and its role in metabolic signaling pathways
Their use for Alcohol Use Disorder (AUD) or drug addiction is considered "off-label." However, groundbreaking clinical research from 2025 and 2026 demonstrates that these medications significantly dampen the brain's reward centers, drastically curbing cravings for alcohol, opioids, and nicotine
Mechanisms of GLP-1 receptor agonist-induced weight loss: A review of central and peripheral pathways in appetite and energy regulation
Conflict of interest DK has received research support from Sanofi, Tanabe Pharma, Terumo, Behringer Ingelheim, Kyowa Kirin, Sumitomo Dainippon Pharma, Ono Pharmaceutical and Takeda Pharmaceutical as well as speaker honoraria from Novo Nordisk Pharma, Sanofi, and Takeda Pharmaceutical